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生命科学中心高明辉课题组在铁死亡领域取得重要进展

来源:亚博棋牌 发布时间: 2020-09-05浏览次数: 17

亚博棋牌HAGONGDABAOXUN(SHENGMING/WEN)JINRI,HAGONGDASHENGMINGKEXUEZHONGXINGAOMINGHUIKETIZUZAIZHUMINGGUOJIXUESHUZAZHI《XINHAOZHUANDAOYUBAXIANGZHILIAO》(Signal Transduction and Targeted Therapy)FABIAOTIWEI《LKB1-AMPKXINHAOTONGLUTONGGUOYIZHIZHIFANGSUANHECHENGERZUDUANTIESIWANG》(LKB1-AMPK Axis Negatively Regulates Ferroptosis by Inhibiting Fatty Acid Synthesis)DEYANJIULUNWEN,JIESHILELKB1-AMPKXINHAOTONGLUZAIDIAOJIETIEHUAISIZHONGDEZHONGYAOZUOYONG。

亚博棋牌TIESIWANG(ferroptosis)SHIJINNIANLAIFAXIANDEYIZHONGYOUTIEYILAIDEYANGHUASUNSHANGYINQIDECHENGXUXINGXIBAOSIWANGXINGSHI,YOUYIXILIETIEHUAISIYOUDAOJIRUerastinHERSL3YINQI。ErastinYIZHIGUANSUAN/GUANGANSUANJIAOHUANQIxCTDEHUOXING,SHIXIBAOZHONGBANGUANGANSUANHEGUGUANGGANTAI(GSH)QUEFA,JINERPOHUAIXIBAOYANGHUAHAIYUANWENTAI,DAOZHITIESIWANGDEFASHENG。GUGUANGGANTAIGUOYANGHUAWUMEI4(GPX4)SHIYIZHONGNENGQINGCHUZHIZHIGUOYANGHUAWUDEMEI,QISHIHUOKEYIZAIBUYINGXIANGXIBAONEIBANGUANGANSUANHEGUGUANGGANTAISHUIPINGDEQINGKUANGXIA,DAOZHITIESIWANGDEFASHENG。YUELAIYUEDUODEZHENGJUBIAOMING,TIESIWANGYUZHONGLIU、XINNAOXUEGUANJIBING、SHENJINGTUIXINGXINGJIBINGDENGZHONGDARENLEIJIBINGXIXIXIANGGUAN。

PUTAOTANGHEGUANXIANANSHIXIBAOSHENGCUNDEBIYAOYINGYANGWUZHI。RANER,BENKETIZUDEQIANQIYANJIUFAXIAN,GUANXIANANDUIYUXIBAOTIESIWANGYESHIBIXUDE。GUANXIANANTONGGUOXIANLITIDAIXIEJINRUSANSUOSUANXUNHUAN,JINERDIAOKONGTIESIWANGDEJINCHENG。LEISIDI,PUTAOTANGJINRUXIBAOHOUJINGTANGJIAOJIETUJINGHESANSUOSUANXUNHUANTUJINGCHANSHENGATPJINERTIGONGXIBAODENENGLIANGXUQIU。DANSHIPUTAOTANGSHIFOUDIAOKONGTIESIWANGSHANGBUQINGCHU。

GAOMINGHUIKETIZUFAXIANPUTAOTANGDEQUESHIKEYIYIZHIYOUerastinHUORSL3YOUDAODETIESIWANG,BIAOMINGPUTAOTANGDUIXIBAOTIESIWANGSHIBIXUDE。AMPKSHIXIBAODEDAIXIEHENENGLIANGGANSHOUQI。DANGPUTAOTANGQUEFASHI,XIBAONEIAMP/ATPBIZHIZENGJIA,JINERJIHUOAMPK。GAIYANJIUFAXIANJIHUOAMPKNENGGOUYIZHITIESIWANGDEFASHENG,ERYIZHIAMPKNENGGOUCUJINTIESIWANGDEFASHENG。AMPKDESHANGYOUJIMEILKB1SHIYIGEFEICHANGGUANJIANDEZHONGLIUYIZHIDANBAI。LKB1ZAIFEIAIDENGZHONGLIUZHONGTUBIANPINLVFEICHANGGAO。GAIYANJIUFAXIANXIEDAILKB1TUBIANDEFEIXIAOXIBAOFEIAIXIBAODUITIESIWANGYICHANGMINGAN。ZHEIBIAOMINGTIESIWANGYOUDAOJIKENENGSHIXIEDAILKB1TUBIANDEZHONGLIUDEYOUXIAOHOUXUANYAOWU。GAIYANJIUJINYIBUFAXIANDANGXIBAOSHOUDAOTIESIWANGCIJISHI,AMPKBEIJIHUO,JINERLINSUANHUABINGYIZHIAMPKXIAYOUDIWUYIXIANFUMEIASUOHUAMEI1(ACC1)DEHUOXING,YIJIYIZHIZHIFANGSUANDEHECHENG,CONGERJIANHUANZHIZHIYANGHUAWUDEJILEIHETIESIWANGDEFASHENG。

GAIYANJIUSHIJIGAOMINGHUIKETIZUFAXIANGUANXIANANDIAOKONGTIESIWANGZHIHOU(Gaoelal. MolecularCell 2015, 2019),ZAIXIBAOYINGYANGDAIXIEYUTIESIWANGLINGYUDELINGYIZHONGYAOFAXIAN。GENGZHONGYAODESHIGAIYANJIUFAXIANXIEDAILKB1TUBIANDEZHONGLIUXIBAODUITIESIWANGCIJIYICHANGMINGAN,ZHEIWEIYABOQIPAIKAIFABAXIANGXIEDAILKB1TUBIANJIYINDEZHONGLIUDETEYIXINGYAOWUDIANDINGLELILUNJICHU。

HAGONGDASHENGMINGKEXUEZHONGXINGAOMINGHUIYANJIUYUANWEIBENWENDETONGXUNZUOZHE,BOSHISHENGLIZHANGZHIWEIDIYIZUOZHE,SHUOSHIYANJIUSHENGDONGXUAN、SHIXIN、CHENKANGJIEHEBOSHIHOUDUWENJINGHEZUOCANYUGAIXIANGGONGZUO,KANGNAIERYIXUEYUANBOSHIZHANGWEISHIGAIWENZHANGDEGONGTONGTONGXUNZUOZHE。GAIYANJIUDEDAOLEGUOJIAZIRANKEXUEJIJIN,HEILONGJIANGSHENGYOUXIUQINGNIANJIJINHEHAERBINGONGYEDAXUERENCAIQIDONGJINGFEIDEZHICHI。

原文链接:


YUANZIHAERBINGONGYEDAXUE,ZUIHOUGENGXINSHIJIAN 2020-09-06

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