亚博棋牌HAGONGDABAOXUN(SHENGMING/WEN)JINRI，HAGONGDASHENGMINGKEXUEZHONGXINGAOMINGHUIKETIZUZAIZHUMINGGUOJIXUESHUZAZHI《XINHAOZHUANDAOYUBAXIANGZHILIAO》（Signal Transduction and Targeted Therapy）FABIAOTIWEI《LKB1-AMPKXINHAOTONGLUTONGGUOYIZHIZHIFANGSUANHECHENGERZUDUANTIESIWANG》（LKB1-AMPK Axis Negatively Regulates Ferroptosis by Inhibiting Fatty Acid Synthesis）DEYANJIULUNWEN，JIESHILELKB1-AMPKXINHAOTONGLUZAIDIAOJIETIEHUAISIZHONGDEZHONGYAOZUOYONG。
亚博棋牌TIESIWANG（ferroptosis）SHIJINNIANLAIFAXIANDEYIZHONGYOUTIEYILAIDEYANGHUASUNSHANGYINQIDECHENGXUXINGXIBAOSIWANGXINGSHI，YOUYIXILIETIEHUAISIYOUDAOJIRUerastinHERSL3YINQI。ErastinYIZHIGUANSUAN/GUANGANSUANJIAOHUANQIxCTDEHUOXING，SHIXIBAOZHONGBANGUANGANSUANHEGUGUANGGANTAI（GSH）QUEFA，JINERPOHUAIXIBAOYANGHUAHAIYUANWENTAI，DAOZHITIESIWANGDEFASHENG。GUGUANGGANTAIGUOYANGHUAWUMEI4（GPX4）SHIYIZHONGNENGQINGCHUZHIZHIGUOYANGHUAWUDEMEI，QISHIHUOKEYIZAIBUYINGXIANGXIBAONEIBANGUANGANSUANHEGUGUANGGANTAISHUIPINGDEQINGKUANGXIA，DAOZHITIESIWANGDEFASHENG。YUELAIYUEDUODEZHENGJUBIAOMING，TIESIWANGYUZHONGLIU、XINNAOXUEGUANJIBING、SHENJINGTUIXINGXINGJIBINGDENGZHONGDARENLEIJIBINGXIXIXIANGGUAN。
PUTAOTANGHEGUANXIANANSHIXIBAOSHENGCUNDEBIYAOYINGYANGWUZHI。RANER，BENKETIZUDEQIANQIYANJIUFAXIAN，GUANXIANANDUIYUXIBAOTIESIWANGYESHIBIXUDE。GUANXIANANTONGGUOXIANLITIDAIXIEJINRUSANSUOSUANXUNHUAN，JINERDIAOKONGTIESIWANGDEJINCHENG。LEISIDI，PUTAOTANGJINRUXIBAOHOUJINGTANGJIAOJIETUJINGHESANSUOSUANXUNHUANTUJINGCHANSHENGATPJINERTIGONGXIBAODENENGLIANGXUQIU。DANSHIPUTAOTANGSHIFOUDIAOKONGTIESIWANGSHANGBUQINGCHU。
GAOMINGHUIKETIZUFAXIANPUTAOTANGDEQUESHIKEYIYIZHIYOUerastinHUORSL3YOUDAODETIESIWANG，BIAOMINGPUTAOTANGDUIXIBAOTIESIWANGSHIBIXUDE。AMPKSHIXIBAODEDAIXIEHENENGLIANGGANSHOUQI。DANGPUTAOTANGQUEFASHI，XIBAONEIAMP/ATPBIZHIZENGJIA，JINERJIHUOAMPK。GAIYANJIUFAXIANJIHUOAMPKNENGGOUYIZHITIESIWANGDEFASHENG，ERYIZHIAMPKNENGGOUCUJINTIESIWANGDEFASHENG。AMPKDESHANGYOUJIMEILKB1SHIYIGEFEICHANGGUANJIANDEZHONGLIUYIZHIDANBAI。LKB1ZAIFEIAIDENGZHONGLIUZHONGTUBIANPINLVFEICHANGGAO。GAIYANJIUFAXIANXIEDAILKB1TUBIANDEFEIXIAOXIBAOFEIAIXIBAODUITIESIWANGYICHANGMINGAN。ZHEIBIAOMINGTIESIWANGYOUDAOJIKENENGSHIXIEDAILKB1TUBIANDEZHONGLIUDEYOUXIAOHOUXUANYAOWU。GAIYANJIUJINYIBUFAXIANDANGXIBAOSHOUDAOTIESIWANGCIJISHI，AMPKBEIJIHUO，JINERLINSUANHUABINGYIZHIAMPKXIAYOUDIWUYIXIANFUMEIASUOHUAMEI1（ACC1）DEHUOXING，YIJIYIZHIZHIFANGSUANDEHECHENG，CONGERJIANHUANZHIZHIYANGHUAWUDEJILEIHETIESIWANGDEFASHENG。
GAIYANJIUSHIJIGAOMINGHUIKETIZUFAXIANGUANXIANANDIAOKONGTIESIWANGZHIHOU（Gaoelal. MolecularCell 2015， 2019），ZAIXIBAOYINGYANGDAIXIEYUTIESIWANGLINGYUDELINGYIZHONGYAOFAXIAN。GENGZHONGYAODESHIGAIYANJIUFAXIANXIEDAILKB1TUBIANDEZHONGLIUXIBAODUITIESIWANGCIJIYICHANGMINGAN，ZHEIWEIYABOQIPAIKAIFABAXIANGXIEDAILKB1TUBIANJIYINDEZHONGLIUDETEYIXINGYAOWUDIANDINGLELILUNJICHU。
HAGONGDASHENGMINGKEXUEZHONGXINGAOMINGHUIYANJIUYUANWEIBENWENDETONGXUNZUOZHE，BOSHISHENGLIZHANGZHIWEIDIYIZUOZHE，SHUOSHIYANJIUSHENGDONGXUAN、SHIXIN、CHENKANGJIEHEBOSHIHOUDUWENJINGHEZUOCANYUGAIXIANGGONGZUO，KANGNAIERYIXUEYUANBOSHIZHANGWEISHIGAIWENZHANGDEGONGTONGTONGXUNZUOZHE。GAIYANJIUDEDAOLEGUOJIAZIRANKEXUEJIJIN，HEILONGJIANGSHENGYOUXIUQINGNIANJIJINHEHAERBINGONGYEDAXUERENCAIQIDONGJINGFEIDEZHICHI。
原文链接: